Each row consists of alternate letters. Thus, first row contains letters V, X, Z ; third row caontains letter P, R, T.
So, the missing letter is E.
The numbers in each column form an arithmetic series . Thus, first column contains number 4, 5, 6. The second column conatains numbers 2, 3, 4.
The numbers in each column will form the series 9, 12, 15.
So, the answer is E12.