H  D  Y  S  M  W  N  B  Q  P  O  C  R  T  B  L  Z  V  E  G  U  F Which two neighbours in the given arrangement are farthest in the alphabetical order ?

Answer: B. D and Y

Clearly, D and Y are neighbours in the given series and are separated by the maximum number of letters i.e, 20 in the English alphabet.